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[Physiological changes in pyridinoline excretion in urine depending on age and sex]
Voprosy Meditsinskoi Khimii
|January 1, 1991
Insights
Pyridoline excretion in urine changes throughout life, with distinct phases observed from childhood to adulthood. Differences between males and females in pyridoline levels were noted during adolescence.
Area of Science:
- Biochemistry
- Human Physiology
- Urine Analysis
Context:
- Pyridoline, a marker of collagen cross-linking, is excreted in urine.
- Understanding age- and sex-related changes in pyridoline excretion is crucial for physiological assessments.
Purpose:
- To investigate age-dependent and sex-specific variations in urinary pyridoline excretion.
- To identify distinct phases of pyridoline excretion across the human lifespan.
Summary:
- Urinary pyridoline excretion exhibits a four-phase pattern with age: increase, decrease, stabilization, and a secondary increase.
- Significant sex-based differences in pyridoline excretion rates were observed specifically in the 16-21 year age group.
Impact:
- Provides normative data for pyridoline excretion across different age groups and sexes.
- Contributes to understanding bone metabolism and aging processes through collagen cross-link analysis.
Abstract:
Natural physiological alterations in excretion of pyridoline (total hydroxypyridoline and lysyl pyridoline) with urine were studied in children and adults depending on age (1-86 years old) and sex. Age-dependent alterations of pyridoline excretion with urine had apparently four phases: an increase, a decrease, stabilization and secondary increase. Distinct dissimilarity between men and women in the rate of pyridoline excretion was found only in the age group of 16-21 years old.