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Invasive pneumococcal disease in children in Ireland--the anticipated benefit of conjugate pneumococcal vaccination

J J Fitzsimons1, A L Chong, M T Cafferkey

  • 1Department of Paediatric Infectious Diseases, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. john.fitzsimons@royalfree.nhs.uk

Irish Journal of Medical Science
|June 28, 2008
PubMed

Insights

Invasive pneumococcal disease (IPD) affects children in Ireland, with an incidence of 10.6/100,000. The 7-valent conjugate pneumococcal vaccine is expected to prevent up to 90% of sepsis and 82.5% of meningitis cases.

Area of Science:

  • Pediatric infectious diseases
  • Vaccinology
  • Epidemiology

Background:

  • Streptococcus pneumoniae causes significant childhood illness.
  • A 7-valent conjugate pneumococcal vaccine is now available in the EU.
  • Pneumococcal disease poses a public health challenge in children.

Purpose of the Study:

  • To determine the incidence and disease burden of invasive pneumococcal disease (IPD) in Irish children.
  • To estimate the potential impact of the 7-valent conjugate pneumococcal vaccine on IPD.
  • To inform public health strategies regarding childhood vaccination.

Main Methods:

  • Retrospective data review of pediatric IPD cases.
  • Epidemiological analysis to calculate incidence rates.
  • Modeling to predict vaccine efficacy against specific IPD types.

Main Results:

  • Ninety-six IPD cases in 95 children were identified, including two deaths.
  • The estimated incidence of childhood IPD in Ireland is 10.6 per 100,000 children.
  • The 7-valent vaccine may prevent up to 90% of sepsis and 82.5% of meningitis cases.

Conclusions:

  • Invasive pneumococcal disease is a major contributor to child mortality and morbidity in Ireland.
  • Routine vaccination with the conjugate pneumococcal vaccine is projected to significantly reduce IPD.
  • Vaccine introduction is expected to benefit both vaccinated and unvaccinated individuals, including older adults, through herd immunity.
Abstract

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