Improved pseudoanalytical solution for steady-state biofilm kinetics
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Updated: Jul 4, 2026

Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
Published on: October 9, 2016
1Department of Civil Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Abstract:
Simple algebraic expressions for the flux of substrate into a steady-state biofilm are developed. This pseudoanalytical solution, which eliminates the need for repetitiously solving numerically a set of nonlinear differential equations, is based on an analysis of the numerical results from the numerical solution of the differential equations. The critical advantage of this new pseudoanalytical solution is that it is highly accurate for the entire range of substrate concentrations and kinetic parameters. The article also illustrates that previous pseudoanalytical solutions for steady-state biofilm kinetics are seriously inaccurate for certain ranges of substrate concentration and kinetic parameters.
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