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Updated: Feb 12, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Comparative in vivo biocompatibility study of single- and multi-wall carbon nanotubes
Aneta Fraczek1, Elzbieta Menaszek, Czeslawa Paluszkiewicz
1AGH - University of Science and Technology, Faculty of Materials Science and Ceramics, 30-059 Krakow, al Mickiewicza 30, Poland. afraczek@op.pl
Abstract:
Carbon nanotubes are expected to be of use in both genetic engineering and biomaterials engineering. In each of these potential areas of application, nanoparticles are introduced into a living organism either in the form of active biomolecule carriers or as a result of the degradation process of an implant. In the present study we focus on the in vivo behavior of two types of carbon nanotubes (single- and multi-wall nanotubes). Raman and Fourier transform infrared spectroscopy, thermogravimetric analysis and differential scanning calorimetry techniques are used to characterize the materials before introducing them into the living system. The nanotubes were implanted into the skeletal rat muscle. A comparative analysis of the tissue reaction to the presence of the two types of carbon nanotubes was made. It was observed that multi-wall carbon nanotubes were found to form large aggregates within the living tissue, while distinctly smaller particles consisting of single-wall nanotubes were easily phagocytosed by macrophages and transported to local lymph nodes.
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