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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jul 4, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

Are dendritic cells central to regulatory T cell function?

Caroline Coquerelle1, Muriel Moser

  • 1Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet, 12, Gosselies 6041, Belgium.

Immunology Letters
|July 1, 2008
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) not only induce immunity but also maintain self-tolerance. This review highlights how DCs use regulatory T cells to achieve immune tolerance, crucial for organismal integrity.

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Last Updated: Jul 4, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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Published on: April 11, 2025

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Area of Science:

  • Immunology
  • Cell Biology
  • Autoimmunity

Background:

  • Dendritic cells (DCs) are well-established immune sentinels and inducers of adaptive immunity.
  • Recent research suggests DCs also play a vital role in maintaining self-tolerance.
  • These dual functions are essential for balancing immune responses against pathogens and self-antigens.

Purpose of the Study:

  • To review the evidence supporting the role of dendritic cells in inducing and maintaining immune tolerance.
  • To explore the mechanisms by which DCs promote tolerance, particularly involving regulatory T cells.

Main Methods:

  • Literature review of experimental evidence and immunological studies.
  • Synthesis of findings on dendritic cell function in immunity and tolerance.
  • Analysis of the role of regulatory T cells in DC-mediated tolerance.

Main Results:

  • Dendritic cells exhibit a dual role in immunity: initiating immune responses and promoting self-tolerance.
  • Experimental data increasingly supports the hypothesis that DCs are critical for maintaining tolerance to self-antigens.
  • A key mechanism involves DCs inducing and sustaining regulatory T cells.

Conclusions:

  • Dendritic cells are central players in both immunity and tolerance.
  • The induction of tolerance by DCs is significantly mediated through regulatory T cells.
  • Understanding DC-mediated tolerance is crucial for managing autoimmune diseases and transplantation outcomes.