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Correction: Covalent engineering of a phenanthroline-modified NH<sub>2</sub>-MIL-53(Al) MOF for the dual-mode sensing of As<sup>3+</sup> and Fe<sup>2+</sup> in complex environmental and dietary matrices.

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Related Experiment Video

Updated: Jul 4, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

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Gallic acid-based indanone derivatives as anticancer agents.

Hari Om Saxena¹, Uzma Faridi, Suchita Srivastava

¹Rain Forest Research Institute, Jorhat, India.

Bioorganic & Medicinal Chemistry Letters

|July 1, 2008

Summary

New gallic acid-based indanone derivatives show potent anticancer activity. Compound 10 is highly effective against hormone-dependent breast cancer cells with no observed toxicity to human red blood cells.

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Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

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Published on: January 21, 2020

Area of Science:

Medicinal Chemistry
Organic Synthesis
Cancer Research

Background:

Indanone derivatives are explored for therapeutic potential.
Gallic acid serves as a key structural motif.

Purpose of the Study:

Synthesize novel gallic acid-based indanone derivatives.
Evaluate their anticancer efficacy and safety profile.

Main Methods:

Synthesis of indanone derivatives.
Anticancer activity assessment using MTT assay.
Cytotoxicity evaluation on human erythrocytes.

Main Results:

Several indanone derivatives exhibited significant anticancer activity.
Compound 10 demonstrated potent activity against MCF-7 cells (IC50=2.2 microM).
Compound 10 showed no toxicity to human erythrocytes at high concentrations, unlike compounds 11, 12, and 14.

Conclusions:

Gallic acid-based indanones are promising anticancer agents.
Compound 10 represents a potential lead for hormone-dependent breast cancer therapy.
Selectivity and safety profile warrant further investigation.