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Published on: March 3, 2011
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex
Stefan Veltel1, Aleksandra Kravchenko, Shehab Ismail
1Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Otto-Hahn-Strasse 11, Dortmund, Germany.
Abstract:
Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.
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