[Preparation of tetrandrine alginate calcium sustained release gel pellets]
Yan Ma1, Wei-zhong Li, Da-wei Chen
1College of Chinese Traditional Medicine, Guangzhou Universtiy of Chinese Medicine, Guangzhou 510405, China. mygzhtcm@163.com
Objective:
To prepare tetrandrine alginate calcium sustained release gel pellets twice daily with Eudragit RS 30D and Eudragit RL 30D.
Methods:
The sustained release gel pellets were prepared by fluid bed technique and release in vitro was selected as the evaluate index. The formulation was optimized by full design test based on the studies of coating factors.
Results:
The optimal coating formulation was shown at the ratio of Eudragit RS 30D and Eudragit RL 30D to 5:1, the loading weight of polymers of 45%, the plasticizer concentration of 20% and 35% talcum powder.
Conclusion:
The perfect sustained release of tetrandrine pellets can be obtained by adjusting the ratio of Eudragit RS 30D and Eudragit RL 30D and the loading weight of polymers.
