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Published on: February 13, 2021
[Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate]
Wen-Guang Zhang1, Shao-Jun Luo, Shao-Fang Zhu
1Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Objective:
To identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).
Methods:
Comparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.
Results:
It showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.
Conclusions:
Abnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.
