Related Experiment Video
Updated: Jul 4, 2026
High-Density Lipoprotein-Specific Phospholipid Efflux Assay
Published on: September 30, 2025
Are serum lipids measured on stroke admission prognostic?
Ana-Maria Simundic1, Nora Nikolac, Elizabeta Topic
1Clinical Institute of Chemistry, Department of Molecular Diagnostics, Sestre milosrdnice University Hospital, Zagreb, Croatia. am.simundic@gmail.com
Background:
It has been hypothesized that serum lipids measured in the early period of stroke are predictive of stroke severity and outcome. The optimal time for lipid measurement is not established. We explored whether lipid profile assessed within the first 24 h after stroke onset: (i) differs from that in stroke-free individuals; (ii) differs between stroke subtypes; and (iii) is predictive of stroke severity and outcome.
Methods:
We prospectively enrolled 70 acute ischemic stroke patients who presented to the Stroke Unit within 24 h of the onset of stroke symptoms, and 68 stroke-free control subjects.
Results:
Triglycerides (p<0.001) and high-density lipoprotein (HDL) cholesterol (p<0.001) were significantly lower in patients than in controls. HDL cholesterol was different across stroke subtypes classified according to the Trial of ORG 10172 in Acute Stroke Treatment scale (p=0.035). Patients with more severe stroke had higher serum triglycerides (odds ratio 2.755; p=0.030).
Conclusions:
Serum triglycerides might serve as a prognostic marker in acute stroke patients.
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