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T lymphocyte activation in patients with active tuberculosis.
1Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
The American Review of Respiratory Disease
|August 1, 1991
Summary
Serum soluble interleukin-2 receptor (sIL-2R) is elevated in active tuberculosis, particularly pulmonary forms. Higher sIL-2R levels correlate with disease extent, suggesting its utility as a marker for tuberculosis activity.
Area of Science:
- Immunology
- Infectious Diseases
- Pulmonology
Background:
- Soluble interleukin-2 receptor (sIL-2R) indicates T lymphocyte activation.
- Tuberculosis (TB) diagnosis and activity assessment require reliable markers.
Purpose of the Study:
- To evaluate serum sIL-2R as a marker for active tuberculosis disease activity and extent.
Main Methods:
- Serum sIL-2R levels were measured in 35 patients with active TB before treatment.
- Patients were categorized by TB manifestation: pulmonary parenchymal lesion, pleural effusion, or lymphadenitis.
- Levels were compared among active TB groups, inactive TB, and healthy controls.
Main Results:
- Serum sIL-2R was significantly elevated in active pulmonary TB (parenchymal lesion and pleural effusion) compared to lymphadenitis, inactive TB, and controls.
- No significant difference in sIL-2R was observed between pulmonary parenchymal lesion and pleural effusion groups.
- A positive correlation was found between sIL-2R levels and the extent of disease on chest radiography (r=0.58, p<0.001).
Conclusions:
- Serum sIL-2R may serve as a valuable biomarker for assessing tuberculosis activity.
- sIL-2R levels correlate with the extent of tuberculous involvement, aiding in disease staging.