Related Experiment Video
Updated: Jul 4, 2026
Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning
Published on: June 9, 2015
Rod a-wave analysis using high intensity flashes adds information on rod system function in 25% of clinical ERG
Josefin Nilsson1, Tom Wright, Carol A Westall
1Department of Clinical Neurophysiology, Sahlgrenska Academy, University of Gothenburg, Blå stråket 7-3 tr, 413 45 Göteborg, Sweden. josefin.nilsson@neuro.gu.se
Purpose:
To investigate whether rod a-wave analysis using high intensity flashes adds information above that obtained with standard ERG.
Methods:
A total of 2,396 eyes were recorded. Patient age was 2.4 months-84.6 years.
Results:
A-wave analysis of high intensity flashes provided additional information on rod system function in 25% of eyes recorded, most importantly in subjects with midretinal disease and artificially reduced rod responses. High intensity flashes also provided measurable responses for longitudinal monitoring in rod dystrophies with non-recordable rod ERGs.
Conclusions:
Clinical ERG testing would benefit greatly from adding high intensity flashes to its standard testing conditions.
