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Updated: Jul 4, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Glucose challenge test does not predict gestational diabetes mellitus.
Martina Montagnana1, Giuseppe Lippi, Giovanni Targher
1Clinical Chemistry Section, Department of Morphological-Biomedical Sciences, University Hospital of Verona, Verona, Italy. martina.montagnana@med.lu.se
The glucose challenge test (GCT) may not be a reliable predictor for gestational diabetes mellitus (GDM). Further research is needed to clarify the diagnostic utility of GCT in GDM screening.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Clinical Diagnostics
Background:
- Gestational diabetes mellitus (GDM) diagnosis and treatment improve maternal and neonatal outcomes.
- The diagnostic value of the glucose challenge test (GCT) for GDM remains debated.
Purpose of the Study:
- To evaluate the diagnostic significance and predictive value of the GCT in identifying GDM.
- To compare GCT results with oral glucose tolerance test (OGTT) in an unselected outpatient population.
Main Methods:
- Retrospective analysis of GCT and OGTT results from 724 female outpatients over 3 years.
- Statistical analysis, including multivariable logistic regression, to identify predictors of GDM.
Main Results:
- GDM was diagnosed in 4.7% of subjects (34 out of 724).
- GCT values did not show statistically significant differences among groups.
- Age, 1-hour OGTT values (≥180 mg/dL), and 2-hour OGTT values (≥155 mg/dL) were independent predictors of GDM.
Conclusions:
- The GCT may not be a reliable predictor for GDM in an unselected population.
- The diagnostic significance of the GCT in GDM screening requires further investigation.
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