Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in post-discharge major adverse cardiovascular events following myocardial infarction: Insights from the veterans healthcare administration.

American journal of preventive cardiology·2026
Same author

Systemic Inflammation and Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease.

JACC. Advances·2026
Same author

Economic burden associated with systemic inflammation in patients with HFmrEF/HFpEF.

American heart journal·2026
Same author

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System.

bioRxiv : the preprint server for biology·2026
Same author

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

Cell·2026
Same author

What does it mean to live with epilepsy? Burden of illness from the patient perspective.

Epilepsia open·2026
Same journal

Author Correction: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Nature cell biology·2026
Same journal

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.

Nature cell biology·2026
Same journal

Primate neurons with special signalling logic.

Nature cell biology·2026
Same journal

Cell surface liposome binding (CLiB) allows lipid-binding probe engineering via high-throughput screening.

Nature cell biology·2026
Same journal

Mapping the human female reproductive tract.

Nature cell biology·2026
Same journal

Learning from stem cell-based embryo models.

Nature cell biology·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Cdh1: a master G0/G1 regulator.

Jeffrey R Skaar1, Michele Pagano

  • 1Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

Nature Cell Biology
|July 2, 2008
PubMed
Summary
This summary is machine-generated.

The study shows that Cdh1, a protein controlling cell cycle phases, is vital for cell survival. Loss of Cdh1 function leads to genomic instability, indicating its role as a tumor suppressor.

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Related Experiment Videos

Last Updated: Jul 4, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Area of Science:

  • Cell biology
  • Molecular biology
  • Genetics

Background:

  • The Anaphase-Promoting Complex/Cyclosome (APC/C) with Cdh1 (APC/C(Cdh1)) regulates key cell cycle transitions.
  • Proper cell cycle control is crucial for preventing uncontrolled cell proliferation and maintaining genomic integrity.

Purpose of the Study:

  • To investigate the essential role of Cdh1 in cell viability and its function in tumor suppression.
  • To determine the consequences of Cdh1 deficiency on genomic stability.

Main Methods:

  • Conditional knockout of the Fizzy-related (Fzr) gene, which encodes Cdh1.
  • Analysis of cell viability and genomic stability in Fzr knockout models.

Main Results:

  • Cdh1 is essential for cell viability.
  • Loss of Cdh1 function results in significant genomic instability.
  • Cdh1 acts as a tumor suppressor by maintaining genomic stability.

Conclusions:

  • Cdh1 plays a critical role in cell cycle regulation and is indispensable for cell survival.
  • Cdh1's function in preventing genomic instability highlights its importance as a tumor suppressor.