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Searching the protein interaction space through the MINT database.

Andrew Chatr-Aryamontri1, Andreas Zanzoni, Arnaud Ceol

  • 1Department of Biology, University of Rome "Tor Vergata", Rome, Italy.

Methods in Molecular Biology (Clifton, N.J.)
|July 2, 2008
PubMed
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The Molecular INTeraction database (MINT) organizes vast protein-protein interaction data. This resource aids researchers in exploring complex biological networks and pathways from published experimental details.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Systems Biology

Background:

  • Fundamental biological processes rely on protein-protein interactions (PPIs).
  • Technological advancements enable large-scale, genome-wide mapping of these interactions.
  • The growing volume of PPI data necessitates structured databases for analysis.

Purpose of the Study:

  • To describe the Molecular INTeraction database (MINT).
  • To provide a structured repository for PPI information.
  • To facilitate the investigation of biological networks and pathways.

Main Methods:

  • Extraction of PPI data from peer-reviewed scientific literature.
  • Systematic curation of experimental details associated with each interaction.
  • Organization of information into a structured database format.

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Main Results:

  • The MINT database serves as a comprehensive resource for PPIs.
  • It stores curated experimental details, enhancing data reliability.
  • The database facilitates the study of biological systems.

Conclusions:

  • MINT is a valuable tool for researchers studying protein interactions.
  • Structured databases are crucial for managing and interpreting large-scale biological data.
  • The database supports advancements in understanding biological networks and pathways.