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Updated: Jul 4, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Testis specific lactate dehydrogenase as target for immunoliposomes.

Ranjna C Dutta¹, Erwin Goldberg

¹Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA. ranjna_dutta@rediffmail.com

American Journal of Reproductive Immunology (New York, N.Y. : 1989)

|July 3, 2008

Summary

Targeting the testis for drug delivery is possible using immunoliposomes. These specifically target lactate dehydrogenase-C4 (LDH-C(4)) on sperm and testes, enabling agent delivery.

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Area of Science:

Reproductive biology
Nanomedicine
Drug delivery systems

Background:

The testis presents a unique challenge for targeted therapeutic agent delivery.
Developing specific delivery mechanisms is crucial for reproductive health interventions.

Purpose of the Study:

To investigate the feasibility of targeted therapeutic agent delivery to the testis.
To evaluate immunoliposomes engineered for testis-specific targeting.

Main Methods:

Immunoliposomes were created by incorporating antibodies against lactate dehydrogenase-C4 (LDH-C(4)).
LDH-C(4) is a protein specifically expressed in the testis.
Targeting and delivery capabilities were assessed in vitro and in vivo.

Main Results:

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Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins

Published on: September 22, 2020

LDH-C(4)-immunoliposomes demonstrated specific recognition of antigens on spermatozoa and testicular tissues.
Effective targeting was observed in both in vitro and in vivo experimental models.

Conclusions:

Targeting lactate dehydrogenase-C4 (LDH-C(4)) is a viable strategy for delivering agents to the testis.
This approach holds potential for both therapeutic and anti-spermatogenic applications.