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The ectomesenchymal chondromyxoid tumor: a review
1College of Dentistry, Division of Oral and Maxillofacial Surgery, Pathology, and Anesthesiology, The Ohio State University, Columbus, OH 43218-2357, USA. allen.12@osu.edu
Oral Diseases
|July 3, 2008
Summary
Ectomesenchymal chondromyxoid tumors are rare oral neoplasms, primarily affecting the tongue. Conservative surgical excision is effective, with a low recurrence rate of less than 10%.
Area of Science:
- Oral Pathology
- Neoplastic Disease Research
- Surgical Oncology
Background:
- Ectomesenchymal chondromyxoid tumor (ECT) is a recently identified neoplasm.
- ECT predominantly affects the oral cavity, particularly the tongue.
- Thirty cases reported since 1995, with a wide age range (9-78 years) and no sex predilection.
Purpose of the Study:
- To summarize the clinicopathological features of ectomesenchymal chondromyxoid tumors.
- To review treatment modalities and outcomes for this rare oral neoplasm.
- To enhance understanding of ECT for improved diagnosis and management.
Main Methods:
- Review of 30 reported cases of ectomesenchymal chondromyxoid tumor.
- Analysis of histopathological characteristics, including growth pattern and background matrix.
- Evaluation of immunohistochemical profiles (GFAP, cytokeratins, S-100, CD-57).
Main Results:
- Tumors typically present as <2 cm lesions on the anterior dorsal tongue.
- Histopathology shows a well-circumscribed, unencapsulated, lobular pattern with myxoid, chondroid, or hyalinized stroma.
- Immunohistochemistry frequently shows positivity for GFAP, cytokeratins, S-100 protein, and CD-57.
Conclusions:
- Ectomesenchymal chondromyxoid tumors are rare, distinct oral neoplasms.
- Conservative surgical excision is the standard treatment.
- Recurrence is uncommon, observed in fewer than 10% of cases, indicating a favorable prognosis.
