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Work-up and management of paediatric Cushing's syndrome

Martin O Savage1, Li F Chan, Ashley B Grossman

  • 1Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK. m.o.savage@qmul.ac.uk

Current Opinion in Endocrinology, Diabetes, and Obesity
|July 3, 2008
PubMed

Insights

Pediatric Cushing's syndrome is rare but serious. Early diagnosis and treatment are vital for good outcomes, though challenges in growth and body composition persist.

Area of Science:

  • Pediatric Endocrinology
  • Endocrinology
  • Pediatric Cushing's Syndrome

Background:

  • Cushing's syndrome in children and adolescents is uncommon but leads to significant morbidity.
  • Management requires specialized expertise, often necessitating collaboration between pediatric endocrinologists and adult specialists.

Purpose of the Study:

  • To present a diagnostic protocol for pediatric Cushing's syndrome.
  • To outline management principles for this condition in young patients.

Main Methods:

  • Utilizes classical endocrine studies alongside novel genetic and advanced imaging techniques.
  • Reviews current therapeutic strategies, including surgical and radiological interventions.

Main Results:

  • Trans-sphenoidal surgery has significantly improved outcomes for Cushing's disease, though pediatric surgical experience is limited.
  • Pituitary radiotherapy serves as an effective second-line treatment option.

Conclusions:

  • Prompt diagnosis and intervention are crucial for optimal long-term prognosis in pediatric Cushing's syndrome.
  • Ensuring normal growth and body composition post-treatment remains a key challenge.
Abstract

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