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Related Experiment Video

Updated: Jul 4, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Glaucoma affects steady state VEP contrast thresholds before psychophysics.

Vaegan¹, Anmar M A Rahman, Gordon F Sanderson

¹School of Optometry and Vision Science, University of New South Wales, New South Wales, Australia. vaegan@unsw.edu.au

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|July 3, 2008

Summary

Steady state visual evoked potentials (ssVEPs) detected glaucoma more effectively than frequency doubling technology (FDT) psychophysical testing. Stricter controls confirmed ssVEPs

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Area of Science:

Ophthalmology
Neuroscience
Visual Psychophysics

Background:

Frequency Doubling Technology (FDT) is a psychophysical test used for glaucoma detection.
FDT measures contrast thresholds to specific visual stimuli (low spatial frequency, high temporal frequency sinusoidal bars).
Previous research suggested steady state visual evoked potentials (ssVEPs) might be more sensitive to glaucoma than FDT.

Purpose of the Study:

To confirm, under stricter experimental controls, that ssVEP contrast thresholds are more sensitive to glaucoma than subjective FDT thresholds.
To investigate the optimization of ssVEP testing for glaucoma detection.

Main Methods:

A double-masked trial involving 57 eyes from 42 subjects.
Estimation of both psychophysical and ssVEP thresholds using a modified binary search.
ssVEP detection defined by a significant signal in any of eight channels; psychophysical testing used a two-alternative forced choice task.

Main Results:

Thresholds and percentage of abnormal results increased with glaucoma severity for ssVEPs, but not for psychophysics.
Both ssVEP and psychophysical threshold measures demonstrated reliability.
SsVEP amplitudes were maximal at 7-10 Hz, approximately 6 cm above the inion, and decreased laterally.

Conclusions:

Under formal controls, ssVEP contrast thresholds to an FDT-like stimulus detected glaucoma more effectively than corresponding psychophysical thresholds.
This finding supports previous, less controlled research and highlights the potential of ssVEPs in glaucoma diagnosis.