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Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007

David W Scheifele1, Julie A Bettinger, Scott A Halperin

  • 1Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia. dscheifele@cw.bc.ca

The Pediatric Infectious Disease Journal
|July 3, 2008
PubMed

Insights

Haemophilus influenzae type b conjugate vaccine effectiveness remains high in Canada. Surveillance shows vaccine failures are rare, even with concurrent vaccinations and longer time since immunization.

Area of Science:

  • Pediatric infectious disease
  • Vaccinology
  • Immunization surveillance

Background:

  • The widespread use of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus/Haemophilus influenzae type b conjugate vaccine (DTaP.IPV/Hib) in Canada allows for continuous monitoring.
  • Assessing vaccine effectiveness is crucial, especially considering new concurrent vaccinations and the duration of immunity.

Purpose of the Study:

  • To evaluate the effectiveness of the DTaP.IPV/Hib vaccine in a Canadian pediatric population.
  • To determine if recent changes in vaccination schedules or time since vaccination impact vaccine failures.

Main Methods:

  • Surveillance data collected from 12 pediatric centers across Canada between 2004 and 2007.
  • Analysis of vaccine failure cases in children who received the DTaP.IPV/Hib vaccine.

Main Results:

  • Vaccine failures associated with the DTaP.IPV/Hib vaccine were found to be rare.
  • The total number of reported cases approached an irreducible minimum.
  • No significant age shift was observed in the cases of vaccine failure.

Conclusions:

  • The DTaP.IPV/Hib vaccine demonstrates sustained high effectiveness in preventing Haemophilus influenzae type b infections.
  • Current vaccination strategies and schedules appear robust, maintaining low incidence rates.
  • Continued surveillance is important to confirm long-term effectiveness and monitor for any emerging trends.

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