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Updated: Jul 4, 2026
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Chronic exposure to ambient levels of urban particles affects mouse lung development
Thais Mauad1, Dolores Helena Rodriguez Ferreira Rivero, Regiani Carvalho de Oliveira
1Department of Pathology, Sao Paulo University Medical School, São Paulo, SP, Brazil. tmauad@usp.br
Rationale:
Chronic exposure to air pollution has been associated with adverse effects on children's lung growth.
Objectives:
We analyzed the effects of chronic exposure to urban levels of particulate matter (PM) on selected phases of mouse lung development.
Methods:
The exposure occurred in two open-top chambers (filtered and nonfiltered) placed 20 m from a street with heavy traffic in São Paulo, 24 hours/day for 8 months. There was a significant reduction of the levels of PM(2.5) inside the filtered chamber (filtered = 2.9 +/- 3.0 microg/m(3), nonfiltered = 16.8 +/- 8.3 microg/m(3); P = 0.001). At this exposure site, vehicular sources are the major components of PM(2.5) (PM
Measurements And Main Results:
Mice exposed to PM(2.5) pre+postnatally presented a smaller surface to volume ratio when compared with nonexposed animals (P = 0.036). The pre+postnatal group presented reduced inspiratory and expiratory volumes at higher levels of transpulmonary pressure (P = 0.001). There were no differences among prenatal and postnatal exposure and nonexposed animals.
Conclusions:
Our data provide anatomical and functional support to the concept that chronic exposure to urban PM affects lung growth.
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