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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Related Experiment Video

Updated: Jul 4, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Primary atrophic solitary morphea profunda.

Elhem Khelifa1, Isabelle Masouyé, Pierre Chavaz

  • 1Clinic of Dermatology, University Hospital of Geneva, Geneva, Switzerland. elhem_khelifa@yahoo.com

Dermatology (Basel, Switzerland)
|July 4, 2008
PubMed
Summary

Solitary morphea profunda (SMP) presented as lipoatrophy-like lesions after vaccination. This case highlights the diverse clinical spectrum of localized scleroderma, emphasizing the need for consideration in differential diagnoses.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Solitary morphea profunda (SMP) is a rare subtype of localized scleroderma.
  • Its etiology remains largely unknown, presenting diagnostic challenges.
  • Localized scleroderma affects the skin and subcutaneous tissues.

Observation:

  • A patient developed noninflammatory, cupuliform depressed plaques on the shoulder post-intramuscular vaccination.
  • Clinical presentation mimicked localized lipoatrophy, lacking typical scleroderma features like induration or pigmentation.
  • Histopathology revealed excessive dermal collagen deposition and hyalinization.

Findings:

  • Magnetic resonance imaging (MRI) showed tissue fibrosis and subcutaneous fat thinning.
  • Electromyography (EMG) confirmed involvement of the adjacent deltoid muscle.
  • Borrelia serology was negative, ruling out Lyme disease as a cause.

Implications:

  • This case expands the known clinical spectrum of localized scleroderma.
  • SMP should be considered in the differential diagnosis of lipoatrophy-like lesions.
  • Early recognition is crucial for appropriate patient workup and management.