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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Related Experiment Video

Updated: Jan 15, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
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Skin Manifestations in VEXAS Syndrome: Specific Clonal Infiltrates versus Non-Specific Reactive Findings.

Samuel Utz1,2, Mathias Lehmann1, S Morteza Seyed Jafari1

  • 1Department of Dermatology, Inselspital Bern University Hospital, Bern, Switzerland.

Case Reports in Dermatology
|October 9, 2025
PubMed
Summary

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome can cause diverse skin lesions in adults. This study details three cases, highlighting diagnostic challenges and histological findings in VEXAS skin manifestations.

Area of Science:

  • Dermatology
  • Rheumatology
  • Hematology

Background:

  • VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an adult-onset inflammatory disorder.
Keywords:
Clonal infiltrateMyelodysplasia cutisParaclonal cutaneous involvementSkin manifestationsVEXAS syndrome

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  • It is myeloid-driven and linked to hematological neoplasms, presenting with systemic symptoms like fever and pancytopenia.
  • Cutaneous manifestations occur in up to 90% of cases but are poorly defined.