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Gamma knife surgery for low-grade gliomas
Peter A Heppner1, Jason P Sheehan, Ladislau E Steiner
1The Lars Leksell Gamma Knife Center, Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Neurosurgery
|September 16, 2008
Summary
Gamma knife surgery offers a safe treatment option for low-grade gliomas, particularly for residual or recurrent tumors. This study shows potential efficacy in managing these brain tumors with acceptable complication rates.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Limited data exists on the long-term effectiveness of Gamma knife surgery for low-grade gliomas.
- Understanding the role of Gamma knife surgery in managing these tumors is crucial.
Purpose of the Study:
- To review the outcomes of patients with low-grade gliomas treated with Gamma knife surgery.
- To assess the long-term efficacy and safety of Gamma knife surgery for low-grade gliomas.
Main Methods:
- Retrospective review of 49 patients with low-grade gliomas treated between 1989 and 2003.
- Median follow-up of 63 months.
- Gamma knife surgery indicated for tumors in eloquent brain areas, residual post-surgery, or late progression.
Main Results:
- Median clinical progression-free survival was 44 months; median radiological progression-free survival was 37 months.
- Five-year radiological progression-free survival was 37% and clinical progression-free survival was 41%.
- Mortality occurred in 14% of patients; 29% achieved complete radiological remission. Complications were observed in 8% of patients, with most resolving without sequelae.
Conclusions:
- Gamma knife radiosurgery demonstrates safety as a treatment for low-grade gliomas.
- It can be considered for patients with residual or recurrent low-grade gliomas.
