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Updated: Jul 4, 2026

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
High-grade cervical disease in adolescents with HIV
L Stewart Massad1, Charlesnika T Evans, Gypsyamber D'Souza
1Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA. massadl@wudosis.wustl.edu
Objective:
To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV.
Materials And Methods:
Review of cervical cytology and biopsy results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study.
Results:
At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed high-grade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p =.13). No cancers were found in adolescents during the study.
Conclusions:
The low incidence of HSIL or CIN 2,3 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.
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