Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Bioequivalence studies: Biowaivers

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2011

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2011

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same author

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology·2010

Same journal

[Proceedings of the XVIII TASPE Seminar, Granada, Spain, 4-5 February 2010].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Treatment algorithm for gastrointestinal graft-versus-host disease].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Treatment of chronic graft-versus-host disease with protein tyrosine kinase inhibitors].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Classification of chronic graft-versus-host disease].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Pegfilgrastim in hematopoietic stem cell transplantation].

Methods and findings in experimental and clinical pharmacology·2011

Same journal

[Allogeneic transplantation in multiple myeloma patients: results and recommendations in February 2010].

Methods and findings in experimental and clinical pharmacology·2011

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Gateways to clinical trials.

A Tomillero, M A Moral

Methods and Findings in Experimental and Clinical Pharmacology

|July 4, 2008

Summary

This summary is machine-generated.

This study provides a comprehensive list of investigational drugs and therapeutic agents, including small molecules, biologics, and vaccines, for various diseases. The findings offer a valuable resource for researchers and clinicians in drug discovery and development.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Related Experiment Videos

Last Updated: Jul 4, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Area of Science:

Pharmacology and Drug Discovery
Biotechnology and Biologics Development
Clinical Trials and Investigational Therapeutics

Background:

The landscape of pharmaceutical research is continuously evolving with novel therapeutic agents.
Identifying and cataloging investigational drugs is crucial for advancing medical science.
A broad overview of current drug candidates aids in understanding research trends and potential treatments.

Purpose of the Study:

To compile a comprehensive list of investigational drugs and therapeutic agents.
To categorize these agents based on their therapeutic class and development stage.
To serve as a reference for researchers, clinicians, and pharmaceutical professionals.

Main Methods:

Systematic compilation of drug names from various sources.
Inclusion of diverse therapeutic modalities such as small molecules, biologics, and vaccines.
Organization of the list for clarity and accessibility.

Main Results:

A detailed enumeration of numerous investigational drugs, including (-)-Epigallocatechin gallate, (-)-Gossypol, Ad.hIFN-beta, Agomelatine, Belimumab, Bortezomib, Curcumin, Denosumab, Eltrombopag, Ipilimumab, Ocrelizumab, Panobinostat, Prasugrel, Regadenoson, Rilonacept, Rivaroxaban, Romiplostim, and others.
Representation of a wide spectrum of therapeutic areas and mechanisms of action.
Inclusion of both novel chemical entities and repurposed compounds.

Conclusions:

The presented list represents a significant collection of investigational agents across different stages of development.
This compilation is a valuable resource for identifying potential therapeutic options and understanding the drug development pipeline.
Further research and clinical evaluation of these agents are warranted to bring novel treatments to patients.