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The descrease of the in vitro proliferative response of zinc-treated stressed mice's thymic lymphocytes.

F García-Tamayo1, N Malpica López, M Aguirre

  • 1Departamento de. Biología, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, D.F., Mexico.

Inflammopharmacology
|July 4, 2008
PubMed
Summary

Chronic inflammation and oxidative stress in newborn mice impair immunity. Zinc acetate supplementation improved immune responses in these stressed mice, suggesting a beneficial prophylactic effect.

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Area of Science:

  • Immunology
  • Neonatal Research
  • Oxidative Stress

Background:

  • Prolonged stimulation of newborn mice with inactivated staphylococci causes chronic inflammation and oxidative stress.
  • This condition leads to anorexia, reduced body weight, and suppressed immune functions, including antibody synthesis and T-lymphocyte proliferation.
  • Stressed mice exhibit adrenal hyperplasia, hypozincemia, and thymic hypoplasia, yet thymic T-lymphocytes show increased proliferation.

Purpose of the Study:

  • To investigate the effects of zinc acetate administration on immune parameters in chronically stressed neonatal mice.
  • To determine if zinc supplementation can mitigate the negative impacts of stress on the immune system.

Main Methods:

  • Newborn mice were subjected to prolonged intraperitoneal injections with inactivated staphylococci.
  • Stressed mice received intramuscular injections of zinc acetate (5 microg) every other day for two weeks.
  • Immune responses, including antibody synthesis, T-lymphocyte proliferation (Con A-stimulated splenic and thymic), zinc concentration, and thymus gland characteristics, were assessed.

Main Results:

  • Zinc acetate treatment reduced zinc concentration in the thymus gland of stressed mice.
  • The in vitro proliferative response of Con A-stimulated T-lymphocytes from stressed mice treated with zinc acetate was reduced.
  • Despite thymic involution due to stress, zinc supplementation showed potential benefits for immune function.

Conclusions:

  • Prophylactic administration of zinc acetate in chronically stressed mice impacts thymus gland zinc levels and T-lymphocyte proliferation.
  • Zinc supplementation may offer beneficial consequences for the immunity of chronically stressed neonatal mice.
  • Further research is warranted to fully elucidate the mechanisms and therapeutic potential of zinc in stress-induced immune dysfunction.