Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

Cholinergic Antagonists: Pharmacokinetics

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and the conjunctiva.

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Decoding Wetting Behavior: Capillary Rise Experiments with Amphiphilic Compounds and Theoretical Aspects.

Langmuir : the ACS journal of surfaces and colloids·2025

Same author

Enhanced capabilities for multi-crystal data collection based on double mesh scans.

Acta crystallographica. Section D, Structural biology·2025

Same author

Correction to "Selecting Counterions to Improve Ionized Hydrophilic Drug Encapsulation in Polymeric Nanoparticles".

Molecular pharmaceutics·2025

Same author

Which diagnoses and arguments regarding severe mental disorder do forensic psychiatric experts in Sweden consider in different cases? A qualitative vignette study.

International journal of law and psychiatry·2024

Same author

Experts' decision-making processes in Swedish forensic psychiatric investigations: A case vignette study.

International journal of law and psychiatry·2023

Same author

Selecting Counterions to Improve Ionized Hydrophilic Drug Encapsulation in Polymeric Nanoparticles.

Molecular pharmaceutics·2023

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Interactions between chitosan-modified particles and mucin-coated surfaces.

Olof Svensson¹, Krister Thuresson, Thomas Arnebrant

¹Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. olof.svensson@mah.se

Journal of Colloid and Interface Science

|July 4, 2008

Summary

Chitosan-modified cubosome particles show strong mucoadhesion to mucin surfaces, indicating potential for mucosal drug delivery. Ellipsometry confirmed robust particle binding, suggesting effective mucoadhesive properties.

More Related Videos

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Published on: February 27, 2021

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Related Experiment Videos

Last Updated: Jul 4, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper

Published on: February 27, 2021

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Area of Science:

Biomaterials Science
Nanotechnology
Surface Chemistry

Background:

Lipid-based cubosome particles are promising for drug delivery.
Surface modification is crucial for enhancing particle functionality.
Chitosan is a biocompatible polymer with mucoadhesive potential.

Purpose of the Study:

To develop and characterize chitosan-modified cubosome particles.
To investigate the mucoadhesive properties of these particles.
To evaluate their potential for mucosal drug delivery applications.

Main Methods:

Surface modification of cubosome particles with chitosan.
Electrophoretic measurements to determine zeta potential and chitosan protonation.
In situ ellipsometry to study particle-mucin interactions.
Assessment of mucoadhesion under physiologically relevant pH conditions.

Main Results:

Chitosan modification optimized to minimize free chitosan.
Zeta potential showed pH dependence linked to chitosan protonation.
Significant adsorption of modified particles to mucin-coated silica surfaces observed at pH 4 and pH 6.
Strong mucoadhesion demonstrated, with <15% particle loss upon rinsing.
Ellipsometry proved effective for studying submicrometer particle mucoadhesion.

Conclusions:

Chitosan-modified cubosome particles exhibit strong mucoadhesive properties.
Electrostatic interactions between chitosan and mucin drive particle adsorption.
These novel particles are suitable candidates for mucosal drug delivery systems.
Ellipsometry is a valuable technique for assessing particle mucoadhesion.