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Updated: Jul 4, 2026
11:34
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
Published on: August 9, 2019
RNA-binding proteins in human genetic disease
Kiven E Lukong1, Kai-wei Chang, Edouard W Khandjian
1Terry Fox Molecular Oncology Group, and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
Trends in Genetics : TIG
|July 4, 2008
Summary
RNA-binding proteins (RBPs) regulate RNA dynamics and are crucial for cell function. Aberrations in RBPs are increasingly linked to complex human diseases, highlighting their role in RNA metabolism disorders.
Area of Science:
- Molecular Biology
- Genetics
- Cellular Biology
Background:
- RNA-binding proteins (RBPs) are critical regulators of RNA metabolism.
- RBPs influence RNA processes including splicing and translation.
- Altered RBP expression impacts cellular physiology and disease.
Purpose of the Study:
- To review emerging evidence on the involvement of RBPs in human diseases.
- To explore the role of RBPs in various disease networks.
- To highlight the connection between RBP defects and complex disorders.
Main Methods:
- Literature review of genetic and proteomic data.
- Analysis of evidence from animal models.
- Synthesis of findings on RBP involvement in disease.
Main Results:
- RBPs are implicated in a wide range of human diseases, including neurological disorders and cancer.
- Evidence suggests RBPs are involved in multiple interconnected disease networks.
- Defects in RNA metabolism due to RBP aberrations are linked to complex diseases.
Conclusions:
- RBPs play a significant role in the pathogenesis of numerous human diseases.
- Dysregulation of RNA metabolism by RBPs may underlie a broad spectrum of complex disorders.
- Further research into RBPs is crucial for understanding and treating human diseases.
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