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Updated: Jul 4, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Bioactive brominated metabolites from the Red Sea sponge Pseudoceratina arabica
Jihan M Badr1, Lamiaa A Shaala, Mohamed I Abou-Shoer
1Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Abstract:
Chemical investigation of the Red Sea sponge Pseudoceratina arabica has led to the isolation and identification of seven brominated compounds including two new bromotyramine derivatives, hydroxymoloka'iamine (2) and moloka'iakitamide (6), and a new brominated phenolic compound, ceratinophenol A (5), together with the known compounds moloka'iamine (1), ceratinamine (3), 5-bromo-2,3-dihydroxy-6-methoxybenzaldehyde (4), and psammaplysin-A (7). Biological evaluation of these metabolites indicated that moloka'iamine and moloka'iakitamide possess significant parasympatholytic effects on isolated rabbit heart and jejunum. This finding has important implications for further biological investigation of this class of compounds. Moreover, these compounds showed weak antibacterial and antifungal activities.
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