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Updated: Jul 4, 2026

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes
Published on: October 28, 2021
How best to recruit the injured lung?
1Pulmonary and Critical Care Medicine, Regions Hospital, University of Minnesota, Minneapolis/St Paul, MN 55101, USA. marin002@umn.edu
Abstract:
Sustained re-opening of collapsed lung tissue (recruitment) requires the application of airway pressures that exceed those of the tidal cycle. The post-maneuver PEEP as well as the duration of high pressure application are also key factors in its success, with their accompanying potential for hemodynamic compromise. Although a wide variety of recruiting maneuvers have been described, the technique that strikes the best balance between efficacy and risk may well vary among patients with differing right heart loading status and lung properties.
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