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Updated: Jul 4, 2026
08:52
Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Vaccine immunogenetics: bedside to bench to population.
Gregory A Poland1, Inna G Ovsyannikova, Robert M Jacobson
1Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. poland.gregory@mayo.edu
Vaccine
|July 5, 2008
Summary
Genetic variations in immune response genes influence how well the measles vaccine works. Identifying these genetic factors can help improve future vaccine development.
Area of Science:
- Immunology
- Genetics
- Vaccinology
Background:
- Human immune responses to vaccines vary significantly, with the underlying genetic basis largely unknown.
- Polymorphisms in immune response genes are suspected contributors to this heterogeneity.
- Understanding these genetic factors is crucial for optimizing vaccine efficacy.
Purpose of the Study:
- To identify specific immune response genes whose polymorphisms are associated with variations in measles vaccine-induced immunity.
- To explore the immunogenetic landscape influencing vaccine response.
Main Methods:
- Analysis of single nucleotide polymorphisms (SNPs) in key immune-related genes.
- Correlation of identified genetic variations with measles vaccine-induced humoral and cellular immune responses.
Main Results:
- Demonstrated associations between SNPs in HLA class I and II genes, cytokine, cell surface receptor, and toll-like receptor genes and immune responses to the measles vaccine.
- Highlighted the impact of specific gene polymorphisms on vaccine-induced immune profiles.
Conclusions:
- Immune response gene polymorphisms significantly influence individual responses to the measles vaccine.
- This research provides insights into genetic restrictions affecting protective immunity and informs the development of next-generation vaccines.
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