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Updated: Jul 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Development of strategies for guiding cardiac resynchronization therapy
Leonard M Rademakers1, Bart W L de Boeck, Jos G Maessen
1Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.
Abstract:
This article illustrates the highly interesting possibilities of cardiac resynchronization therapy (CRT) yet also discusses several problems for optimal implementation. The authors have presented possible strategies to improve CRT by designing and using better measurements of mechanical dyssynchrony or discoordination, leading to better patient selection. In addition, application of CRT can be improved by developing techniques to reach the optimal pacing site(s) easier and algorithms for easier programming of optimal atrioventricular delay and interventricular interval. Also, application of CRT in patients with less severe heart failure deserves further attention. Finally, the mechanism of ventricular interaction may open new fields of application of left ventricle-based pacing in patients who have heart failure, even with a narrow QRS complex.
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