Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual-Scale StaphAIR: Predictive Modeling for the Diagnosis of <i>S. aureus</i> Infection via Simultaneous Detection and Quantification of Cytokines and Antibodies.

Analytical chemistry·2026

Same author

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugs.

bioRxiv : the preprint server for biology·2026

Same author

Validation of Dried Saliva for Molecular Diagnostics.

ACS measurement science au·2026

Same author

A multi-readout photonic sensor for rapid diagnosis of Von Willebrand disease.

Npj biosensing·2026

Same author

QuickDraw: detecting HIV in whole blood using an integrated paper-based consumable that enables direct amplification of purified RNA from paper.

Lab on a chip·2026

Same author

Multi-zone patterning enables hematocrit-independent precision metering of dried plasma for decentralized diagnostics.

Lab on a chip·2025

Same journal

Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection.

Biosensors & bioelectronics·2026

Same journal

A novel capillary-driven dual-mode imaging flow cytometry system for malaria parasite detection and quantification.

Biosensors & bioelectronics·2026

Same journal

Liver-targeted alkaline phosphatase-activatable fluorescent probe for imaging liver fibrosis and screening anti-fibrotic natural products.

Biosensors & bioelectronics·2026

Same journal

GLASS-seq: a gel-anchored, ligation-assisted, scalable biosensing platform for low-cost regional spatial transcriptomics.

Biosensors & bioelectronics·2026

Same journal

CRISPR/Cas12a-based dual-modal signal platform using MIL-101(Fe) for colorimetric and electron spin resonance detection of HPV-16 nucleic acid.

Biosensors & bioelectronics·2026

Same journal

Fully automated centrifugal microfluidic system for self-calibrating isothermal nucleic acid quantification.

Biosensors & bioelectronics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)

Published on: May 3, 2011

Detection of human proteins using arrayed imaging reflectometry.

Charles R Mace¹, Christopher C Striemer, Benjamin L Miller

¹Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, United States.

Biosensors & Bioelectronics

|July 5, 2008

Summary

This summary is machine-generated.

Arrayed imaging reflectometry (AIR) offers a label-free biosensing platform for detecting human proteins in complex biological samples like serum. This technology demonstrates high sensitivity and selectivity for crucial biomarkers.

More Related Videos

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jul 3, 2026

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)

Published on: May 3, 2011

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

Area of Science:

Biotechnology and Biosensing
Proteomics and Biomarker Discovery

Background:

Protein arrays are essential for understanding biological processes and diagnosing diseases.
Complex biological samples (e.g., serum, cell lysates) present challenges due to high protein content.
Assay robustness, selectivity, and sensitivity are critical for reliable protein detection.

Purpose of the Study:

To evaluate the suitability of arrayed imaging reflectometry (AIR) for detecting human proteins in complex mixtures.
To demonstrate the application of AIR for sensitive and selective cytokine detection.

Main Methods:

Utilized a previously disclosed label-free biosensing platform: arrayed imaging reflectometry (AIR).
Performed array-based detection of cytokines in buffered solutions.
Validated AIR performance using undiluted human serum samples.

Main Results:

Demonstrated AIR's high suitability for detecting human proteins within complex solutions.
Successfully detected cytokines in both buffered solutions and undiluted human serum.
AIR platform exhibits robustness, selectivity, and sensitivity for protein analysis.

Conclusions:

Arrayed imaging reflectometry (AIR) is a powerful label-free technology for analyzing complex biological samples.
AIR shows significant promise for disease biomarker discovery and diagnostic applications.
The platform's ability to detect proteins in undiluted serum highlights its practical utility.