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Updated: Jun 11, 2026

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

Liquid-phase mass transfer coefficients in bioreactors.

Y Kawase¹, B Halard, M Moo-Young

¹Biochemical Engineering Group, Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada.

Biotechnology and Bioengineering

|May 1, 1992

Summary

A new model predicts liquid-phase mass transfer coefficients in bioreactors using surface renewal theory. The model shows good agreement with experimental data from bubble column reactors, aiding bioprocess optimization.

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Area of Science:

Biochemical Engineering
Mass Transfer Phenomena
Bioreactor Design

Background:

Accurate liquid-phase mass transfer coefficients are crucial for optimizing bioreactor performance.
Existing models may not fully capture the complexities of mass transfer in various bioreactor types.

Purpose of the Study:

To develop and validate a theoretical model for predicting liquid-phase mass transfer coefficients in bioreactors.
To assess the model's applicability to different fermentation broths and bioreactor configurations.

Main Methods:

Development of a theoretical model based on the surface renewal concept.
Experimental determination of volumetric mass transfer coefficients in a bench-scale bubble column reactor.
Estimation of specific surface area using established correlations.

Main Results:

The proposed surface renewal model provides reasonable predictions of liquid-phase mass transfer coefficients.
Model predictions show good agreement with experimental data for Chaetomium cellulolyticum fermentation broth and carboxymethyl cellulose media.
Validation against literature data from bubble column and stirred tank bioreactors supports the model's generalizability.

Conclusions:

The surface renewal concept offers a viable theoretical basis for modeling liquid-phase mass transfer in bioreactors.
The developed model can aid in the design and scale-up of bioreactors for bioprocesses.
Further studies can explore model refinement for more complex systems and operating conditions.