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Updated: Jul 3, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Chronic migraine associated with the Chiari type 1 malformation
1Inonu University, Turgut Ozal Medical Center, Department of Neurology, Malatya, Turkey. yukselkablan@yahoo.com
Clinical Neurology and Neurosurgery
|July 8, 2008
Summary
Patients with Chiari malformation type 1 (CM-1) show a higher frequency of chronic migraine. This study found CM-1 may be linked to chronic migraine, with earlier onset and increased pain intensity.
Area of Science:
- Neurology
- Headache Medicine
- Neuroimaging
Background:
- Chiari malformation type 1 (CM-1) is a structural defect in the cerebellum.
- The relationship between CM-1 and migraine, particularly chronic migraine, requires further investigation.
Purpose of the Study:
- To determine the prevalence of migraine in patients diagnosed with CM-1.
- To characterize the clinical features of migraine in this patient cohort.
Main Methods:
- A cohort of 73 patients with CM-1 were evaluated for migraine using International Headache Society criteria.
- Patients with other intracranial, parenchymal, or cervical lesions were excluded.
- Clinical and demographic data were compared between CM-1 patients with migraine and a control group with chronic migraine but without CM-1.
Main Results:
- 15.06% of CM-1 patients had migraines, with 10.95% having chronic migraines.
- Compared to controls, CM-1 patients with migraine exhibited earlier pain onset, more frequent headache days, higher pain intensity, and increased associated symptoms like nausea and vomiting.
- Physical activity aggravated pain significantly more in the CM-1 group.
Conclusions:
- The overall frequency of migraine in CM-1 patients is comparable to general population studies.
- A threefold increase in chronic migraine frequency was observed in CM-1 patients.
- CM-1 is suggested as a potential contributing factor to the development of chronic migraine.
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