Related Experiment Video
Updated: Jul 3, 2026
Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
A case of relapsing secondary bladder adenocarcinoma after right colonic cancer
Luciano Izzo1, Dario Pietrasanta, Paolo Izzo
1La Sapienza University, Rome, Italy. luciano.izzo@uniroma1.it
Background:
A 71-year-old woman was referred to a surgical oncology clinic after CT raised suspicion for a bladder neoplasm. She had previously undergone right hemicolectomy and received adjuvant chemotherapy for pT3N1MX cancer of the cecum. A retroperitoneal recurrence had been deemed unsuitable for surgical resection, and had instead been treated with chemoradiation therapy. Follow-up CT raised suspicion for a possible bladder neoplasm.
Investigations:
CT, physical examination, urinalysis, cystoscopy with biopsy, pathological analysis and immunohistochemical analysis.
Diagnosis:
Adenocarcinoma of the cecum metastatic to the bladder.
Management:
The patient underwent open bladder resection with total excision of the neoplasm and was administered adjuvant chemotherapy consisting of irinotecan and cetuximab. Subsequent recurrences at the same site were treated with transurethral resection, while chemotherapy was still in progress. At 7 months' follow-up, the patient remained alive, with no evidence of further recurrence.
