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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Mechanisms of Retrovirus-induced Cancers

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Related Experiment Video

Updated: Jul 3, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Small RNAs and cancerogenesis.

S S Ryazansky¹, V A Gvozdev

¹Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia. ryazansky@img.ras.ru

Biochemistry. Biokhimiia

|July 9, 2008

Summary

Dysfunctional microRNAs and short interfering RNAs (siRNA) are key indicators in cancer development and progression. These molecules influence gene expression and epigenomic modifications, offering new diagnostic and therapeutic targets in cancer epigenomics.

Area of Science:

Molecular Biology
Cancer Research
Epigenetics

Background:

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally.
Aberrant miRNA expression is a hallmark of various cancers.
Short interfering RNAs (siRNAs) are involved in gene silencing and chromatin modification.

Purpose of the Study:

To review the role of microRNA disturbances in cancer.
To highlight the involvement of short interfering RNA (siRNA) in cancer epigenomics and chromatin structure.
To discuss future directions in cancer epigenomics focusing on siRNA-mediated modifications.

Main Methods:

Literature review of studies on microRNA and siRNA in cancer.
Analysis of the functional roles of these small RNAs in gene regulation and epigenetics.

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Last Updated: Jul 3, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Synthesis of current knowledge on siRNA's impact on chromatin structure and cancer transformation.

Main Results:

Disturbances in microRNA generation and function are specific diagnostic features of cancer.
Short interfering RNA (siRNA) plays a role in modifying epigenomic chromatin structure, potentially leading to cancer transformation.
siRNA's involvement in epigenomic modification is a critical area for future cancer epigenomics research.

Conclusions:

MicroRNAs are crucial regulators whose dysregulation signifies cancer.
siRNA-mediated epigenomic modifications represent a significant mechanism in cancer development.
Targeting siRNA pathways in epigenomics offers promising avenues for future cancer diagnostics and therapeutics.