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Related Experiment Videos

Protein structure protection commits gene expression patterns.

Jianping Chen1, Han Liang, Ariel Fernández

  • 1Program in Applied Physics, Rice Quantum Institute, Rice University, Houston, TX 77005, USA. jpchen@ric.edu

Genome Biology
|July 9, 2008
PubMed
Summary
This summary is machine-generated.

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Protein structure vulnerability quantifies gene dosage sensitivity and guides expression patterns. This vulnerability signals post-transcriptional regulation, impacting mRNA levels as surrogates for protein expression.

Area of Science:

  • Structural biology
  • Systems biology
  • Genomics

Background:

  • Gene co-expression patterns define protein module formation in space and time.
  • Limited research has linked expression correlations to the 3D structures of gene products.

Purpose of the Study:

  • To investigate the link between protein structure and gene expression regulation.
  • To analyze how protein structural vulnerability influences transcriptome organization.

Main Methods:

  • Global structure-based analysis of yeast and human proteomes.
  • Contrast structural data with transcriptome data from microarray analysis.
  • Interrelate protein vulnerability, intrinsic disorder, and co-expression patterns.

Main Results:

Related Experiment Videos

  • Protein vulnerability quantifies dosage sensitivity in metabolic and tissue-specific expression.
  • Vulnerability determines co-expression similarity of binding partners.
  • Extremely vulnerable human proteins show significant micro-RNA targeting, impacting mRNA as protein expression surrogates.
  • Yeast protein expression vulnerability is linked to protein aggregation, with prions identified among vulnerable proteins.

Conclusions:

  • Protein structural vulnerability quantifies dosage sensitivity and drives gene expression patterns.
  • Highly vulnerable proteins are subject to significant post-transcriptional regulation.
  • Protein vulnerability acts as a structure-encoded signal for post-transcriptional regulation in both yeast and humans.