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A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling

Katharine H Wrighton1, Fangyan Dai, Xin-Hua Feng

  • 1Michael E. DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Developmental Cell
|July 9, 2008
PubMed

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...