Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risks and Familial Coaggregation of Autism Spectrum Disorder Among First-Degree Relatives of Individuals With Colorectal Cancer.

Psychiatry investigation·2026
Same author

Multi-Site Hymenoptera Stings Mark a High-Risk Subgroup in the Emergency Department.

The Kaohsiung journal of medical sciences·2026
Same author

Evaluation of sternoclavicular joint infection in adults, 2020 to 2025.

Medicine·2026
Same author

Adverse Childhood Experiences and Psychological Health in Patients with Myasthenia Gravis: A Study Incorporating an Online Positive Mental Health Learning Program.

Healthcare (Basel, Switzerland)·2026
Same author

Monocyte Distribution Width as a Biomarker for Predicting Bacteremia: A Retrospective Study in the Emergency Department.

Life (Basel, Switzerland)·2026
Same author

Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter.

International journal of molecular sciences·2025
Same journal

Diagnostic accuracy of emergency department triage systems for predicting clinical severity: A systematic review and meta-analysis of five-level triage scales.

The American journal of emergency medicine·2026
Same journal

Methanol toxicity from inhalational abuse of a methyl acetate-containing nail polish remover.

The American journal of emergency medicine·2026
Same journal

Regarding strategies, feasibility of implementations and results of HIV screening in emergency departments.

The American journal of emergency medicine·2026
Same journal

Rocuronium dosing for rapid sequence intubation: A retrospective analysis in ED and ICU settings.

The American journal of emergency medicine·2026
Same journal

Clinical features of adults with undiagnosed acute leukemia in the emergency department: A descriptive study.

The American journal of emergency medicine·2026
Same journal

Occult intraperitoneal gynecological hemorrhage: An under-evaluated source of hemoperitoneum after blunt trauma.

The American journal of emergency medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Acute perforated appendicitis with leukopenic presentation.

Yen-Yi Feng1, Yen-Chun Lai, Yu-Jang Su

  • 1Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan.

The American Journal of Emergency Medicine
|July 9, 2008
PubMed
Summary
This summary is machine-generated.

Acute appendicitis is typically indicated by a high white blood cell count. However, rare cases present with a normal or low white blood cell count, posing a diagnostic challenge in emergency departments.

Related Experiment Videos

Last Updated: Jul 3, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

  • Emergency Medicine
  • Surgical Pathology
  • Diagnostic Imaging

Background:

  • Acute appendicitis commonly presents with leukocytosis (elevated white blood cell count).
  • Leukopenic presentation (low white blood cell count) in acute appendicitis is uncommon.
  • Misdiagnosis can occur in emergency settings when appendicitis mimics other conditions with normal or low white blood cell counts.

Observation:

  • A 38-year-old male presented with right lower quadrant abdominal pain and fever.
  • Laboratory results revealed a significantly low white blood cell count of 1800/microL.
  • Computed tomography (CT) scan demonstrated appendiceal wall thickening and fluid within the lumen.

Findings:

  • The patient was diagnosed with acute appendicitis despite the atypical leukopenic presentation.
  • Computed tomography imaging was crucial in identifying the inflamed appendix.
  • An emergent appendectomy was performed for definitive treatment.

Implications:

  • This case highlights the importance of considering acute appendicitis even in the absence of leukocytosis.
  • Clinical history, physical examination, and advanced imaging are vital for accurate diagnosis of appendicitis.
  • Awareness of leukopenic appendicitis can improve diagnostic accuracy and patient outcomes in emergency settings.