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Longitudinal imaging: change and causality.

Jennifer L Whitwell1

  • 1Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA. whitwell.jennifer@mayo.edu

Current Opinion in Neurology
|July 9, 2008
PubMed
Summary
This summary is machine-generated.

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Longitudinal MRI studies show brain atrophy correlates with cognitive decline in dementia and multiple sclerosis. Further research is needed to establish its role in epilepsy progression.

Area of Science:

  • Neurology
  • Radiology

Background:

  • Longitudinal magnetic resonance imaging (MRI) studies are increasingly used for neurological disorders.
  • These include degenerative dementia, multiple sclerosis, and epilepsy.

Purpose of the Study:

  • To review the utility of longitudinal MRI in assessing disease progression.
  • To highlight recent findings and identify areas for future research.

Main Methods:

  • Review of recent longitudinal MRI studies.
  • Analysis of correlations between brain atrophy and clinical outcomes.
  • Investigation of underlying causes of brain atrophy.

Main Results:

  • Brain atrophy rates correlate with cognitive and functional decline in dementia and multiple sclerosis.

Related Experiment Videos

  • Advanced MRI techniques detail regional patterns of brain loss.
  • Correlations found between atrophy rates and protein deposits (dementia) or lesion burden (multiple sclerosis).
  • Longitudinal data for epilepsy remain inconsistent.

    • Conclusions:

    • Longitudinal MRI is a valuable biomarker for disease progression in dementia and multiple sclerosis.
    • The role of longitudinal imaging in epilepsy requires further investigation.