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Related Experiment Video

Updated: Jul 3, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Carotid artery stenting 2008.

J Van Laanen1, J M Hendriks, M R H M Van Sambeek

  • 1Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Panminerva Medica
|July 9, 2008
PubMed
Summary
This summary is machine-generated.

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Carotid artery stenting (CAS) is a viable alternative to carotid endarterectomy (CEA) for high-risk patients. However, for standard-risk patients, CAS is not proven non-inferior and may be worse if performed by inexperienced operators.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Neurosurgery

Background:

  • Carotid artery stenting (CAS) has emerged as a less invasive alternative to surgical carotid endarterectomy (CEA).
  • CAS is an evolving technique with improving procedural safety and outcomes.
  • Minimizing interventions is a key goal in managing cerebrovascular disease.

Purpose of the Study:

  • To evaluate the efficacy and safety of CAS compared to CEA in patients with symptomatic and asymptomatic extracranial obstructive disease.
  • To determine the comparative outcomes of CAS and CEA based on patient risk stratification and operator experience.

Main Methods:

  • Review of individual randomized clinical trials comparing CAS and CEA.
  • Analysis of outcomes in different patient subgroups, including high-risk and standard-risk symptomatic patients.

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Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
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  • Consideration of the impact of operator experience and the use of embolic protection devices.

    • Main Results:

    • CAS demonstrated equivalent or potentially superior outcomes compared to CEA in high-risk patients.
    • In standard-risk symptomatic patients, CAS did not prove non-inferior to CEA.
    • Outcomes for CAS were worse in standard-risk patients when performed by inexperienced operators without embolic protection compared to experienced CEA surgeons.

    Conclusions:

    • CAS is a suitable alternative to CEA for high-risk patients undergoing treatment for carotid artery disease.
    • For standard-risk symptomatic patients, CEA remains the preferred treatment, especially when performed by experienced surgeons.
    • Further research is needed to optimize CAS techniques and determine its role in specific patient populations.