Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug induced suicidal ideation.

R Z Fisch1, A Lahad

  • 1Department of Psychiatry, Shaare Zedek Medical Center, Jerusalem, Israel.

The Israel Journal of Psychiatry and Related Sciences
|January 1, 1991
PubMed
Summary

A man experienced brief, unwanted suicidal thoughts after taking the antifungal drug ketoconazole. This rare adverse drug reaction highlights potential psychological side effects of medications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Opportunities and challenges in delivering remote primary care during the Coronavirus outbreak.

BMC primary care·2022
Same author

Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.

Clinical and experimental immunology·2018
Same author

Exome sequencing as a differential diagnosis tool: resolving mild trichohepatoenteric syndrome.

Clinical genetics·2014
Same author

Thirty years of family medicine publications in Israel (1975-2004): what, where, and how much?

Journal of the American Board of Family Medicine : JABFM·2009
Same author

Attitudes of couples identified through screening as carriers of Gaucher disease type 1.

Clinical genetics·2008
Same author

Insoles for prevention and treatment of back pain.

The Cochrane database of systematic reviews·2007

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Clinical Psychiatry

Background:

  • Adverse drug reactions can manifest in various ways, including psychiatric symptoms.
  • Suicidal ideation is a serious symptom that requires careful consideration of potential triggers.
  • Ketoconazole is an antifungal medication with a known side effect profile.

Observation:

  • A mentally healthy individual developed ego-alien, obsessional-like suicidal ideas and images.
  • These ideations occurred transiently after the ingestion of ketoconazole.
  • The patient remained fully conscious and did not exhibit mood disturbances congruent with suicidal thoughts.

Findings:

  • This case study reports a rare instance of drug-induced suicidal ideation.
  • The suicidal ideas were ego-dystonic (not aligned with the person's self-perception) and mood-incongruent.
  • This suggests a potential direct neurochemical effect of ketoconazole on mood and thought processes.

Implications:

  • This case underscores the importance of considering medication side effects in the differential diagnosis of psychiatric symptoms.
  • Further research is needed to understand the mechanisms behind drug-induced suicidal ideation.
  • Clinicians should be vigilant for unusual psychological reactions to ketoconazole and other medications.

Related Experiment Videos