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Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis
Luo Zhang1, Xiangdong Wang, Demin Han
1Key Laboratory Otolaryngology, Capital Medical University, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing, PR China. luozhang@trhos.com
Conclusion:
The results of our study demonstrated the association between the single nucleotide polymorphisms (SNPs) of GATA-3 and allergic rhinitis (AR).
Objective:
AR is considered to be controlled by T-helper type 2 (Th2) cells. GATA-3 is the crucial transcription factor controlling the differentiation and function of Th2 cells. We aimed to evaluate the association between the SNPs of GATA-3 and AR.
Subjects And Methods:
GATA-3 SNPs in 109 AR patients and 112 healthy controls in China were detected with restriction fragment length polymorphism.
Results:
The genotypes at rs1269486 were GG, GA, and AA, and the genotypes at rs2229360 were CC, CT, and TT. The frequency of the G allele in the patient group was significantly higher than that in the control group (p<0.01), while the frequency of the A allele in the patient group was significantly lower than that in the control group (p<0.01). Meanwhile, the haplotype frequency of GC at the two loci in the patient group was significantly higher than that in the control group (p<0.01), and the haplotype frequency of AC in the patient group was significantly lower than that in the control group (p<0.01).
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