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Vesicular aceclofenac systems: a comparative study between liposomes and niosomes
Maha Nasr1, Samar Mansour, Nahed D Mortada
1Faculty of Pharmacy, Department of Pharmaceutics, Ain Shams University, Cairo, Egypt. maha2929@gmail.com
Journal of Microencapsulation
|July 9, 2008
Summary
Niosomes and liposomes effectively deliver aceclofenac for sustained anti-inflammatory effects. Niosomes demonstrate superior stability and efficacy compared to liposomes for topical drug delivery.
Area of Science:
- Pharmaceutics
- Drug Delivery Systems
- Nanotechnology
Background:
- Vesicular systems act as local depots for sustained drug release.
- Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID).
Purpose of the Study:
- To prepare and comparatively evaluate aceclofenac multilamellar liposomes and niosomes.
- To assess the stability and in vitro drug release of these vesicular systems.
- To evaluate the in vivo anti-inflammatory efficacy of aceclofenac-loaded vesicles.
Main Methods:
- Preparation of aceclofenac multilamellar liposomes and niosomes.
- Characterization of vesicles: entrapment efficiency, particle size, shape, differential scanning calorimetry.
- In vitro drug release studies.
- Stability studies at 2-8°C for 3 months.
- In vivo anti-inflammatory assessment using the rat paw oedema technique.
Main Results:
- Entrapment efficiency and in vitro release were tunable by altering cholesterol content, surfactant type, and charge.
- Niosomes exhibited enhanced stability over liposomes.
- Both systems provided sustained anti-inflammatory activity compared to the marketed product.
- Niosomes demonstrated superior anti-inflammatory effects over liposomes.
Conclusions:
- Aceclofenac-loaded niosomes and liposomes are effective topical anti-inflammatory delivery systems.
- Niosomes offer advantages in stability and efficacy for topical NSAID delivery.
- Formulation parameters can be optimized to control drug release and improve therapeutic outcomes.
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