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Apha-adrenergic receptor blockade increases human REM sleep.

I Oswald, V R Thacore, K Adam

    British Journal of Clinical Pharmacology
    |April 1, 1975
    PubMed
    Summary
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    Thymoxamine, an alpha-adrenergic blocker, increased REM sleep and awakenings while reducing slow-wave sleep in early night sleep. Later, slow-wave sleep increased, suggesting REM and NREM sleep interdependence.

    Area of Science:

    • Neuroscience
    • Sleep Medicine
    • Pharmacology

    Background:

    • Alpha-adrenergic receptors play a role in regulating sleep.
    • Noradrenaline levels may influence REM sleep duration.

    Purpose of the Study:

    • To investigate the effects of thymoxamine on sleep architecture in young adults.
    • To explore the relationship between alpha-adrenergic blockade and sleep stages.

    Main Methods:

    • Administration of thymoxamine (150 mg i.v.) to young adults.
    • Monitoring sleep stages, including REM and slow-wave sleep (stage 3+4).
    • Control experiments to assess effects on blood pressure.

    Main Results:

    • Thymoxamine increased REM sleep duration and brief awakenings in early night sleep.

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  • Slow-wave sleep (stage 3+4) was diminished in early night but increased in later night.
  • Thymoxamine did not affect blood pressure.

    • Conclusions:

    • REM sleep duration might be inversely related to central alpha-adrenoceptor noradrenaline availability.
    • Sleep control mechanisms for REM and NREM sleep appear interdependent.