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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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Related Experiment Video

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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

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Published on: November 1, 2018

Dengue and liver disease.

Ira Shah1

  • 1Department of Pediatrics, B. J. Wadia Hospital for Children, Mumbai, India. irashah@pediatriconcall.com

Scandinavian Journal of Infectious Diseases
|July 9, 2008
PubMed
Summary

Severe liver damage, known as acute hepatitis, and hepatic encephalopathy are uncommon in Dengue Hemorrhagic Fever (DHF). This study highlights a high mortality rate in children with DHF experiencing both conditions.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • Dengue hemorrhagic fever (DHF) is a severe mosquito-borne viral illness.
  • Acute hepatitis and hepatic encephalopathy are rare but serious complications of DHF.

Purpose of the Study:

  • To report on pediatric cases of severe hepatic dysfunction secondary to DHF.
  • To highlight the clinical presentation and outcomes of children with DHF-associated hepatitis and encephalopathy.

Main Methods:

  • Case series reporting on four pediatric patients.
  • Clinical data review focusing on presentation, management, and outcomes.

Main Results:

  • Four children (8 months to 3 years) presented with severe hepatic dysfunction.

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  • Three male infants also developed hepatic encephalopathy.
  • Two of the three infants with hepatic encephalopathy died, indicating high mortality.

    • Conclusions:

    • DHF can manifest with severe hepatitis and hepatic encephalopathy in children.
    • The co-occurrence of hepatitis and encephalopathy in DHF presents a critical, high-mortality condition in pediatric patients.