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Updated: Jul 3, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
The Open-Trial Selective Reminding Test (OT-SRT) as a tool for the assessment of learning and memory
Nancy D Chiaravalloti1, Julie Balzano, Nancy B Moore
1Kessler Medical Rehabilitation Research and Education Center, Neuropsychology and Neuroscience Laboratory, West Orange, NJ 07052, USA. nchiaravalloti@kmrrec.org
Abstract:
The Open Trial Selective Reminding Test (OT-SRT) is a modification of the SRT that also evaluates new learning abilities. The examinee is asked to learn a list of 10 words over a maximum of 15 trials. Using a criterion-referenced approach, the list is repeatedly administered until a criterion of complete recall on two consecutive trials is achieved. Training to criterion provides a better assessment of learning ability than the traditional fixed trial list-learning paradigm. Recall and recognition is then tested 30 and 90 minutes following the learning trials. This paper presents normative data on the OT-SRT for 117 healthy controls (Study 1) and 151 participants with clinically definite multiple sclerosis (Study 2).
