Related Experiment Video
Updated: Jul 3, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
Published on: March 9, 2019
Pharmacokinetics and biodistribution of nanoparticles
1School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Abstract:
Nanoparticles show their promise for improving the efficacy of drugs with a narrow therapeutic window or low bioavailability, such as anticancer drugs and nucleic acid-based drugs. The pharmacokinetics (PK) and tissue distribution of the nanoparticles largely define their therapeutic effect and toxicity. Chemical and physical properties of the nanoparticles, including size, surface charge, and surface chemistry, are important factors that determine their PK and biodistribution. The intracellular fate of the nanoparticles after cellular internalization that affects the drug bioavailability is also discussed. Strategies for overcoming barriers for intracellular delivery and drug release are presented. Finally, future directions for improving the PK of nanoparticles and perspectives in the field are discussed.
Related Concept Videos
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics: Overview
Biopharmaceutics and Pharmacokinetics: Overview
Drug Distribution: Tissue Binding
For...
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship

